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Therapy with androgenic anabolic steroids may decrease levels of thyroxine-binding globulin resulting in decreased total T 4 serum levels and increase resin uptake of T 3 and T 4, thereby decreasing serum free T 4 concentrations and increasing serum thyroxine levels.[6] Anecdotal reports support the hypothesis that therapeutic administration of androgenic anabolic steroids reduces the amount and/or type of T4 by decreasing urinary T 4 and T3 concentrations. Clinical Trials Four randomized studies have investigated the effects of aromatase inhibitor treatments of azoospermic men. Five of the studies examined testosterone treatment: two randomized controlled trials.[5] One randomized controlled trial compared and aromatase inhibitor with placebo administration of oral testosterone (400, 800, and 1600 mg) in men with androgen deficiency associated with low serum T. The study found that androgen receptor-positive patients receiving 400, 800, and 1600 mg of testosterone had significantly reduced testosterone to serum concentrations.[5] The other randomized controlled trial demonstrated that androgen receptor-positive patients treated with testosterone (400, 800, and 1600 mg/week for 18 weeks) demonstrated significantly lower T-testosterone concentrations than those in the placebo group at the final end point.[6] The fourth randomized controlled trial examined the efficacy of aromatase inhibitor with oral testosterone (400, 800, and 1600 mg/week for 18 weeks) on the level of free T (normalization to testosterone at T levels <50 ng/mL). At the final end point, androgen receptor-positive patients treated with testosterone significantly reduced free T levels compared to those treated with placebo; however, total T concentration was not significantly different between the 2 comparison groups.[7] The fifth of the 4 randomized studies examined the effect of or aromatase inhibitor in the treatment of azoospermia. In this study, the aromatase inhibitor isosorbide dinitrate (500, 1000, 2000, 3000, 4000 mg/week for 10 weeks), with 400, 800, and 1600 mg/week of testosterone, achieved serum T levels of 507, 501, 501, and 503 ng/mL at the final levels obtained in patients who had not lost any semen (the final free T concentration ranged from 1085 to 1135 ng/mL). At the final end point, mean total T 4 concentrations were reduced relative to the control group (from 1055 to 1046 ng/mL) in patients treated with testosterone. At the end point, total T 2 concentration was also significantly lower in the placebo group, from 1602 to 1566 ng/mL.[8] In each of the 4 randomized studies, the aromatase Related Article:
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